Sheffield Wednesday take on Brentford at Hillsborough Stadium in the Sky Bet Championship. The Owls came behind to beat the Bees 2-1 in this game last season.
Dutch champions Ajax face Liverpool in the UEFA Champions League at the Amsterdam Arena. The two sides meet for the first time since the 1966/67 European Cup.
Manchester City welcome Porto to the Etihad Stadium in Group C of the Champions League. City will be hoping for a repeat of last season's group stages in which they went unbeaten.
A Friday night derby clash from the Sky Bet Championship as Nottingham Forest welcome local rivals Derby County to the City Ground. Forest won 1-0 in this fixture last season.
Two sides relegated from last season's Premier League clash at Vicarage Road as Watford welcome Bournemouth for the early kick-off from the Sky Bet Championship.
Manchester City travel to the London Stadium to take on West Ham in their latest Premier League test.
Ole Gunnar Solskjaer's Manchester United welcome Frank Lampard's Chelsea to Old Trafford in Saturday evening action from the Premier League.
Ralph Hasenhuttl's Southampton welcome Carlo Ancelotti's Everton to St Mary's Stadium. The Toffees come into this riding high after an unbeaten start to the season.
Nuno Espirito Santo's Wolverhampton Wanderers welcome Steve Bruce's Newcastle United to Molineux for the second part of a Super Sunday double-header.
Sean Dyche's Burnley take on Jose Mourinho's Tottenham Hotspur at Turf Moor in Monday Night Football from the Premier League.